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上海起發(fā)實(shí)驗(yàn)試劑有限公司

signalchemlifesciences

時(shí)間：2017-4-12閱讀：1974
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signalchemlifesciences——激酶研究

SignalChem Lifesciences Corporation (“SLC”)公司總部位于加拿大不列顛哥倫比亞，是激酶研究領(lǐng)域的企業(yè)，其兩大核心產(chǎn)品系列為生物試劑及研究服務(wù)與藥物研發(fā)服務(wù)部。生物試劑及研究服務(wù)（SignalChem Pharmaceuticals Inc）始于2004年，致力于研發(fā)和生產(chǎn)生物醫(yī)藥研究和藥物研發(fā)領(lǐng)域的激酶產(chǎn)品，目前擁有的激酶/表觀遺傳相關(guān)酶類及其檢測(cè)試劑產(chǎn)品超過(guò)2000種，覆蓋幾乎所有激酶靶點(diǎn)以及表觀遺傳研究相關(guān)酶類，以及多種信號(hào)蛋白相關(guān)產(chǎn)品。同時(shí)，為輔助檢測(cè)激酶及臨床疾病和個(gè)體化治療，SignalChem還在生物標(biāo)志物及診斷試劑盒領(lǐng)域有著數(shù)十年的積淀，擁有強(qiáng)大和豐富的相關(guān)產(chǎn)品。藥物研發(fā)服務(wù)部致力于尋找新的小分子激酶抑制劑，并用于臨床治療。憑借公司豐富的激酶特異性小分子復(fù)合物資源庫(kù)，以及公司在激酶研究領(lǐng)域強(qiáng)大研究團(tuán)隊(duì)和豐富研究經(jīng)驗(yàn)，SLC在以激酶及其通路為靶點(diǎn)的藥物設(shè)計(jì)、研發(fā)和生產(chǎn)具有*優(yōu)勢(shì)，目前公司已擁有大量的以激酶為靶點(diǎn)的小分子抑制劑產(chǎn)品，可用于研究各種腫瘤等疾病。蛋白激酶是聯(lián)結(jié)所有細(xì)胞活動(dòng)的中樞，通過(guò)過(guò)表達(dá)/過(guò)度激活及突變蛋白激酶可導(dǎo)致機(jī)體功能異常進(jìn)而引發(fā)疾病，因此靶向激酶的藥物有著重要的臨床應(yīng)用價(jià)值。蛋白激酶家族是僅次于G蛋白偶聯(lián)受體家族的第二大藥物靶點(diǎn)，目前已發(fā)現(xiàn)約518種野生型的激酶族以及與其相關(guān)的臨床突變案例，有超過(guò)30種FDA認(rèn)證的激酶抑制劑。憑借著多年來(lái)以激酶為核心的細(xì)胞信號(hào)相關(guān)產(chǎn)品研發(fā)積累，以及為科研院所及制藥企業(yè)科研服務(wù)經(jīng)驗(yàn)，SignalChem在抑制激酶活性的藥物領(lǐng)域處于水平，公司不僅擁有zui大的且不斷成長(zhǎng)的活性激酶及突變激酶產(chǎn)品線，以及可在多個(gè)檢測(cè)平臺(tái)實(shí)施的激酶活性檢測(cè)試劑盒，而且不斷與多個(gè)大型制藥企業(yè)和研究院所廣泛合作，公司的主要產(chǎn)及服務(wù)包括：

1、憑借公司強(qiáng)大的科研力量和經(jīng)驗(yàn)，SignalChem推出的“Kinome Search Engine”激酶篩選系統(tǒng)，可對(duì)每一個(gè)激酶族中的單個(gè)激酶做出檢測(cè)，從而輔助和加快激酶藥物的研發(fā)。

2、“Kinome Search Engine”激酶篩選系統(tǒng)不僅可輔助設(shè)計(jì)激酶藥物，還可進(jìn)一步研究人類激酶族的功能和機(jī)制，加深對(duì)未知激酶的認(rèn)識(shí)，尋找更多的藥物靶點(diǎn)，（目前認(rèn)證的藥物僅僅有少于5%是以已知的激酶通路為靶點(diǎn)，因此激酶通路作為藥物靶點(diǎn)有著巨大的潛力和價(jià)值）。

3、SignalChem公司擁有激酶相關(guān)臨床突變數(shù)據(jù)庫(kù)，在研究疾病復(fù)發(fā)和抗藥領(lǐng)域的核心問(wèn)題時(shí)有著的優(yōu)勢(shì)，可以更為有效地協(xié)助制藥企業(yè)進(jìn)行藥物研發(fā)。

除了藥物研發(fā)方面的優(yōu)勢(shì)，SignalChem還在生物標(biāo)志物及診斷試劑盒領(lǐng)域有著數(shù)十年的積淀，擁有強(qiáng)大和豐富的相關(guān)產(chǎn)品。

目前SLC公司的產(chǎn)品覆蓋了幾乎所有細(xì)胞內(nèi)激酶相關(guān)通路，包括AKT/PKB通路、ERK/MAPK通路、JAK/STAT通路、JNK/SAPK通路、NfkB通路、p38通路、PKA/PKC通路、WNT信號(hào)通路等，適用于血管再生、凋亡和自噬、腫瘤、心血管疾病、細(xì)胞周期、細(xì)胞應(yīng)激、胞內(nèi)酪氨酸激酶、炎癥、浸潤(rùn)和轉(zhuǎn)移、脂質(zhì)激酶、代謝性疾病、神經(jīng)生物學(xué)、磷酸酶/磷酸二酯酶、受體酪氨酸激酶、Ser/Thr激酶等研究領(lǐng)域。主要產(chǎn)品有：

 

一、蛋白酶類產(chǎn)品系列

 1、高活性乙酰轉(zhuǎn)移酶

品名

貨號(hào)

種屬

標(biāo)記類型

表達(dá)系統(tǒng)

氨基序列

基因號(hào)

KAT2A (GCN5), Active

K311-381G

Human

GST tag

Sf9 insect cells

323-end

NM_021078

KAT2B (PCAF), Active

K311-381BG

Human

GST tag

Sf9 insect cells

431-end

NM_003884

KAT3A (CREBBP), Active

K312-381G

Human

GST tag

Sf9 insect cells

1319-1710

NM_004380

KAT5 (TIP60), Active

K314-380G

Human

GST tag

Sf9 insect cells

Full Length

NM_006388

KAT6B (MYST4), Active

K315-381BG

Human

GST tag

Sf9 insect cells

431-end

NM_012330

KAT7 (MYST2), Active

K316-380G

Human

GST tag

Sf9 insect cells

Full Length

NM_007067

 

2、高活性精氨酸脫亞氨酶

品名

貨號(hào)

種屬

標(biāo)記類型

表達(dá)系統(tǒng)

氨基序列

基因號(hào)

PAD Cocktail, Active

P312-37C

-

-

-

Full Length

-

      

3、高活性GTP/ATP酶

品名

貨號(hào)

種屬

標(biāo)記類型

表達(dá)系統(tǒng)

氨基序列

基因號(hào)

CDC42, Active

C108-310GH

Human

GST/His

E.coli

Full length

NM_001791

GNAI1, Active 

G121-310G

Human

GST tag

E.coli

2-end

NM_002069

GNAI2, Active 

G122-310G

Human

GST tag

E.coli

2-end

NM_002070

GNAI3, Active 

G123-310G

Human

GST tag

E.coli

2-end

NM_006496

GNAS, Active 

G127-310G

Human

GST tag

E.coli

Full length

NM_000516

HRAS1 (Mature form), Active

R105-310H

Human

His tag

E.coli

2-186

NM_005343

KRAS (Mature form), Active

R106-310H

Human

His tag

E.coli

2-186

NM_033360

NRAS (Mature form), Active

R107-310H

Human

His tag

E.coli

2-186

NM_002524

RAC1, Active

R103-310G

Human

GST tag

E.coli

Full length

NM_006908

RAC2, Active

R104-310H

Human

His tag

E.coli

Full length

NM_002872

RAC3, Active

R102-310H

Human

His tag

E.coli

Full length

NM_005052

RhoA (Mature form), Active

R144-310H

Human

His tag

E.coli

1-190

NM_001664

RhoC (Mature form), Active

R144-310CH

Human

His tag

E.coli

1-190

NM_175744

RhoD (Mature form), Active

R144-310DH

Human

His tag

E.coli

1-207

BC001338

VCP, Active 

V116-310G

Human

GST tag

Sf9 insect cells

Full length

NM_007126

      

4、高活性組蛋白去乙?；?/span>

品名

貨號(hào)

種屬

標(biāo)記類型

表達(dá)系統(tǒng)

氨基序列

基因號(hào)

HDAC1, Active

H83-30G

Human

GST tag

Sf9 insect cells

Full Length

NM_004964

HDAC10, Active

H92-31G

Human

GST tag

Sf9 insect cells

1-482

NM_032019

HDAC11, Active

H93-30G

Human

GST tag

Sf9 insect cells

Full Length

NM_024827

HDAC2, Active

H84-30G

Human

GST tag

Sf9 insect cells

Full Length

NM_001527

HDAC3, Active

H85-30G

Human

GST tag

Sf9 insect cells

Full Length

NM_003883

HDAC3/NCOR2, Active

H85-38G

Human

GST tags

Sf9 insect cells

HDAC3 (full-length)/

NCOR2 (237-489)

NM_003883

HDAC4, Active

H86-31G

Human

GST tag

Sf9 insect cells

612-end

NM_006037

HDAC5, Active

H87-31G

Mouse

GST tag

Sf9 insect cells

617-end

BC060609

HDAC6, Active

H88-30G

Human

GST tag

Sf9 insect cells

Full Length

BC069243

HDAC7, Active

H89-31G

Human

GST tag

Sf9 insect cells

501-end

NM_015401

HDAC8, Active

H90-30H

Human

His tag

Sf9 insect cells

Full Length

BC050433

 

5、活性突變激酶（共計(jì)253種）

品名

貨號(hào)

種屬

標(biāo)記類型

表達(dá)系統(tǒng)

氨基序列

基因號(hào)

ABL1 Mutant (E255K), Active

A03-12BG

Human

GST tag

Sf9 insect cells

27-end (E255K)

NM_005157

ABL1 Mutant (E255V), Active

A03-12HH

Human

His tag

Sf9 insect cells

27-end (E255V)

NM_005157

ABL1 Mutant (F317I), Active

A03-12JG

Human

GST tag

Sf9 insect cells

27-end (F317I)

NM_005157

ABL1 Mutant (F317L), Active

A03-12IG

Human

GST tag

Sf9 insect cells

27-end (F317L)

NM_005157

ABL1 Mutant (G250E), Active

A03-12CG

Human

GST tag

Sf9 insect cells

27-end (G250E)

NM_005157

ABL1 Mutant (H396P), Active

A03-12LG

Human

GST tag

Sf9 insect cells

27-end (H396P)

NM_005157

ABL1 Mutant (M351T), Active

A03-12KG

Human

GST tag

Sf9 insect cells

27-end (M351T)

NM_005157

ABL1 Mutant (Q252H), Active

A03-12FG

Human

GST tag

Sf9 insect cells

27-end (Q252H)

NM_005157

ABL1 Mutant (T315I), Active

A03-12DG

Human

GST tag

Sf9 insect cells

27-end (T315I)

NM_005157

ABL1 Mutant (V299L), Active

A03-12MG

Human

GST tag

Sf9 insect cells

27-end (V299L)

NM_005157

ABL1 Mutant (Y253F), Active

A03-12EG

Human

GST tag

Sf9 insect cells

27-end (Y253F)

NM_005157

ABL1 Mutant (Y253H), Active

A03-12GH

Human

His tag

Sf9 insect cells

27-end (Y253H)

NM_005157

AKT1 Mutant (E17K), Active

A16-12G

Human

GST tag

Sf9 insect cells

Full length (E17K)

NM_005163

AKT2 Mutant (E17K), Active

A17-12G

Human

GST tag

Sf9 insect cells

Full length (E17K)

NM_001626

AKT2 Mutant (R274H), Active

A17-12BG

Human

GST tag

Sf9 insect cells

Full length (R274H)

NM_001626

AKT3 Mutant (E17K), Active

A18-12G

Human

GST tag

Sf9 insect cells

Full Length (E17K)

NM_005465

AKT3 Mutant (G171R), Active

A18-12BG

Human

GST tag

Sf9 insect cells

Full length (G171R)

NM_005465

ALK Mutant (C1156Y), Active

A19-12DG

Human

GST tag

Sf9 insect cells

1060-end (C1156Y)

NM_004304

ALK Mutant (F1174L), Active

A19-12EG

Human

GST tag

Sf9 insect cells

1060-end (F1174L)

NM_004304

ALK Mutant (F1174S), Active

A19-12FG

Human

GST tag

Sf9 insect cells

1060-end (F1174S)

NM_004304

ALK Mutant (G1202R), Active

A19-12HG

Human

GST tag

Sf9 insect cells

1060-end (G1202R)

NM_004304

ALK Mutant (G1269A), Active

A19-12JG

Human

GST tag

Sf9 insect cells

1060-end (G1269A)

NM_004304

ALK Mutant (G1269S), Active

A19-12KG

Human

GST tag

Sf9 insect cells

1060-end (G1269S)

NM_004304

ALK Mutant (L1152R), Active

A19-12CG

Human

GST tag

Sf9 insect cells

1060-end (L1152R)

NM_004304

ALK Mutant (L1196M), Active

A19-12GG

Human

GST tag

Sf9 insect cells

1060-end (L1196M)

NM_004304

ALK Mutant (R1275Q), Active

A19-12LG

Human

GST tag

Sf9 insect cells

1060-end (R1275Q)

NM_004304

ALK Mutant (S1206R), Active

A19-12IG

Human

GST tag

Sf9 insect cells

1060-end (S1206R)

NM_004304

ALK Mutant (T1151M), Active

A19-12BG

Human

GST tag

Sf9 insect cells

1060-end (T1151M)

NM_004304

ALK Mutant (T1151_L1152insT), Active

A19-12G

Human

GST tag

Sf9 insect cells

1060-end (T1151_L1152insT)

NM_004304

ALK2 Mutant (PF197_198L), Active

A06-12FG

Human

GST tag

Sf9 insect cells

147-end (PF197_198L)

NM_001105

ALK2 Mutant (Q207D), Active

A06-13CG

Human

GST tag

Sf9 insect cells

147-end (Q207D)

NM_001105

ALK2 Mutant (Q207E), Active

A06-13DG

Human

GST tag

Sf9 insect cells

147-end (Q207E)

NM_001105

ALK2 Mutant (R206H), Active

A06-12BG

Human

GST tag

Sf9 insect cells

147-end (R206H)

NM_001105

ALK3 Mutant (Q233D), Active

B04-12BG

Human

GST tag

Sf9 insect cells

187-end (Q233D)

NM_004329

ALK3 Mutant (R486Q), Active

B04-12CG

Human

GST tag

Sf9 insect cells

187-end (R486Q)

NM_004329

AXL Mutant (R499C), Active

A34-12BG

Human

GST tag

Sf9 insect cells

473-end (R499C)

NM_021913

BCR-RET Mutant, Active

R02-19EG

Human

GST tag

Sf9 insect cells

1-426 (BCR) - 713-end (RET)

BC066122

BRAF Mutant (d485-489 P490Y), Active

B08-12IG

Human

GST tag

Sf9 insect cells

381-end or exon 9-18 (d485-489 P490Y)

NM_004333

BRAF Mutant (G464V), Active

B08-12JG

Human

GST tag

Sf9 insect cells

381-end or exon 9-18 (G464V)

NM_004333

BRAF Mutant (G469A), Active

B08-12FG

Human

GST tag

Sf9 insect cells

381-end or exon 9-18 (G469A)

NM_004333

BRAF Mutant (K601E), Active

B08-12BG

Human

GST tag

Sf9 insect cells

416-end (K601E)

NM_004333

BRAF Mutant (L597V), Active

B08-12HG

Human

GST tag

Sf9 insect cells

381-end or exon 9-18 (L597V)

NM_004333

BRAF Mutant (R506_K507insVLR), Active

B08-13CG

Human

GST tag

Sf9 insect cells

381-end or exon 9-18 (R506_K507insVLR)

NM_004333

 

6、活性激酶

該產(chǎn)品系列共包括445種激酶產(chǎn)品，下表僅列部分.

品名

貨號(hào)

種屬

標(biāo)記類型

表達(dá)系統(tǒng)

氨基序列

基因號(hào)

ABL1, Active

A03-11H

Mouse

His tag

Sf9 insect cells

27-end

NM_009594

ABL1, Active

A03-18H

Human

His tag

Sf9 insect cells

27-end

NM_005157

ABL2, Active

A04-11H

Human

His tag

Sf9 insect cells

38-end

NM_005158

ACK, Active

A05-11G

Human

GST tag

Sf9 insect cells

110-476

NM_005781

AKT1, Active

A16-10G

Human

GST tag

Sf9 insect cells

Full Length

NM_005163

AKT2, Active

A17-10H

Human

His tag

Sf9 insect cells

Full Length

NM_001626

AKT2, Active

A17-10G

Human

GST tag

Sf9 insect cells

Full Length

NM_001626

AKT3, Active

A18-10G

Human

GST tag

Sf9 insect cells

Full Length

NM_005465

 

7、高活脂質(zhì)激酶

品名

貨號(hào)

種屬

標(biāo)記類型

表達(dá)系統(tǒng)

氨基序列

基因號(hào)

DGKA, Active 

D21-10G

Human

GST tag

Sf9 insect cells

Full length

NM_001345

PI3K (p110 alpha (E545K)/p85 alpha), Active 

P27-152H

Human

His tags

Sf9 insect cells

Full length

NM_006218

PI3K (p110 alpha (N345K(/p85 alpha), Active 

P27-122CH

Human

His tags

Sf9 insect cells

Full length

NM_006218

PI3K (p110 alpha(E542K)/p85 alpha, Active 

P27-122DH

Human

His tags

Sf9 insect cells

Full length

NM_006218

PI3K (p110 alpha/p55 gamma), Active 

P27-102CH

Human

His tag

Sf9 insect cells

Full length

NM_006218

PI3K (p110 alpha/p85 alpha), Active 

P27-102G

Human

GST tags

Sf9 insect cells

Full length

NM_006218

PI3K (p110 alpha/p85 alpha), Active 

P27-102H

Human

His tags

Sf9 insect cells

Full length

NM_006218

PI3K (p110 alpha/p85 alpha), Active 

P27-182H

Mouse

His tags

Sf9 insect cells

Full length

NM_008839

PI3K (p110 beta/p85 alpha), Active 

P28-102H

Human

His tags

Sf9 insect cells

Full length

NM_006219

PI3K (p110 beta/p85 beta), Active 

P28-102BH

Human

His tags

Sf9 insect cells

Full length

NM_006219

PI3K (p110 delta/p85 alpha), Active 

P30-102H

Human

His tags

Sf9 insect cells

Full length

NM_005026

PI3K (p120 gamma), Active 

P29-102H

Human

His tag

Sf9 insect cells

Full length

NM_002649

PI4K2A, Active 

P21-102G

Human

GST tag

Sf9 insect cells

Full length

NM_018425

PI4K2B, Active 

P22-102G

Human

GST tag

Sf9 insect cells

Full length

NM_018323

PI4KA, Active 

P31-102G

Human

GST tag

Sf9 insect cells

Full length

NM_002650

PI4KB, Active 

P32-102G

Human

GST tag

Sf9 insect cells

Full length

BC000029

PIK3C2A, Active 

P23-112G

Human

GST tag

Sf9 insect cells

299-end

NM_002645

PIK3C2B, Active 

P24-112BG

Human

GST tag

Sf9 insect cells

850-end

BC144342

 

8、高活性甲基轉(zhuǎn)移酶

品名

貨號(hào)

種屬

標(biāo)記類型

表達(dá)系統(tǒng)

氨基序列

基因號(hào)

COMT, Active

C339-381G

Human

GST tag

Sf9 insect cells

27-271

NM_000754

DNMT3A, Active

D353-380G

Human

GST tag

Sf9 insect cells

Full Length

BC043617

DNMT3B, Active

D353-380BG

Human

GST tag

Sf9 insect cells

Full Length

BC111933

DNMT3L, Active

D353-380CG

Human

GST tag

Sf9 insect cells

Full Length

BC002560

DOT1L (KMT4), Active 

D344-381G

Human

GST tag

Sf9 insect cells

1-435

NM_032482

EHMT1 (KMT1D), Active 

E317-381G

Human

GST tag

Sf9 insect cells

895-end

NM_024757

EHMT2, Active

E318-381G

Human

GST tag

Sf9 insect cells

807-end

NM_006709

LCMT1, Active 

L321-380G

Human

GST tag

Sf9 insect cells

Full length

NM_016309

MLL1 (KMT2A), Active 

M341-381G

Human

GST tag

Sf9 insect cells

3738-end

NM_005933

MLL2 (KMT2D), Active 

M342-381G

Human

GST tag

Sf9 insect cells

5317-end

NM_003482

MLL3 (KMT2C), Active 

M343-381G

Human

GST tag

Sf9 insect cells

4689-end

NM_170606

 

9、高活性磷酸酶

品名

貨號(hào)

種屬

標(biāo)記類型

表達(dá)系統(tǒng)

氨基序列

基因號(hào)

CDC2, Active

C04-20G

Human

GST tag

Sf9 insect cells

Full Length

NM_001789

CDC25B, Active

C04-20BG

Human

GST tag

Sf9 insect cells

Full Length

NM_021873

CDC25C, Active

C04-20CG

Human

GST tag

Sf9 insect cells

Full Length

BC019089

DUSP22 (MKPX), Active

D22-20G

Human

GST tag

E.coli

Full Length

NM_020185

PP1A, Active

P13-20G

Human

GST tag

Sf9 insect cells

Full Length

NM_002708

PP1B, Active

P14-20G

Human

GST tag

Sf9 insect cells

Full Length

NM_002709

PP2A alpha/PPP2R1A Complex, Active

P16-20BH

Human

His tags

Sf9 insect cells

Full length

NM_002715

PP2Aalpha, Active

P16-20G

Human

GST tag

Sf9 insect cells

Full Length

NM_002715

 

10、高活性磷酸二酯酶

品名

貨號(hào)

種屬

標(biāo)記類型

表達(dá)系統(tǒng)

氨基序列

基因號(hào)

PDE10A, Active

P98-31G

Human

GST tag

Sf9 insect cells

71-end

NM_006661

PDE1A, Active

P89-30H

Human

His tag

Sf9 insect cells

Full Length

NM_005019

PDE1B, Active

P89-30BG

Human

GST tag

Sf9 insect cells

Full Length

NM_000924

PDE1C, Active

P89-30CG

Human

GST tag

Sf9 insect cells

Full Length

NM_005020

PDE2A, Active

P90-30G

Human

GST tag

Sf9 insect cells

Full Length

NM_002599

PDE3A, Active

P91-31G

Human

GST tag

Sf9 insect cells

669-end

NM_000921

PDE3B, Active

P91-31BG

Human

GST tag

Sf9 insect cells

654-end

NM_000922

PDE4A, Active

P92-31G

Human

GST tag

Sf9 insect cells

332-end

NM_001111307

PDE4B, Active

P92-31BG

Human

GST tag

Sf9 insect cells

305-end

NM_002600

PDE4C, Active

P92-31CG

Human

GST tag

Sf9 insect cells

287-end

NM_000923

 

11、高活性蛋白酶

品名

貨號(hào)

種屬

標(biāo)記類型

表達(dá)系統(tǒng)

氨基序列

CPB (carboxypeptidase B), Active

C560-31N

Rat

tag-free

Yeast cells

109-end

EK (enterokinase), Active

E535-31H

Swine

His tag

Yeast cells

800-end

Immobilized Lys-c, Agarose

L585-31AN

Bacteria

tag-free

E.coli

206-473 aa

Immobilized Lys-c, Silica

L585-31SN

Bacteria

tag-free

E.coli

206-473 aa

Immobilized Thrombin, Agarose

T565-31AN

Human

Native

 

 

Immobilized Trypsin, Agarose

T575-31AN

Swine

tag-free

Yeast cells

10-end

Immobilized Trypsin, Silica

T575-31SN

Swine

tag-free

Yeast cells

10-end

KEX2 Protease, Active

K525-31N

Yeast

tag-free

Yeast cells

110-660 aa

Lys-c (lysyl-endopeptidase), Active

L585-31N

Bacteria

tag-free

E.coli

206-473 aa

 

二、抗體產(chǎn)品系列

1、亞型特異性抗體

品名

貨號(hào)

宿主

應(yīng)用

Anti-AKT3

A18-63R

Rabbit

WB

Anti-AMPK alpha 1

P47-63R

Rabbit

WB

Anti-CAMK1

C07-60M

Mouse, IgG1, 5H8

WB

Anti-CHK2

C48-60M

Mouse, IgG1, 7F9

WB

Anti-ERK1

M29-60M

Mouse, IgG1, E32

WB, IP

Anti-ERK1

M29-60BM

Mouse, IgG1, E19

WB, IP

Anti-GSK3 alpha

G08-63R

Rabbit

WB

Anti-GSK3 beta

G09-60M

Mouse, IgG1, 6C2

WB

Anti-HSP90 beta

H36-63R

Rabbit

WB

 

2、偶聯(lián)修飾的抗體

品名

貨號(hào)

宿主

應(yīng)用

Anti-5-Methylated Cytosine (5-methyl cytosine)

C92-67S

Sheep, IgG

WB, IP

Anti-Acetylated Lysine

L95-66R

Rabbit

WB, ELISA, PI, IHC, IF

Anti-Acetylated Lysine, Biotin Conjugated

L95-66BR

Rabbit

WB, ELISA, IF, IHC, IP

Anti-Acetylated Lysine, FITC Conjugated

L95-66CR

Rabbit

For direct immunofluorescence assay

Anti-Acetylated Lysine, HRP Conjugated

L95-66DR

Rabbit

WB, ELISA, IF, IHC, IP

Anti-Methylated Arginine (NG, NG-Di-methyl)

A96-67R

Rabbit

WB, ELISA, IF, IHC, IP

Anti-Methylated Arginine (NG-Mono-methyl)

A95-67R

Rabbit

WB, ELISA, IF, IHC, IP

Anti-Methylated Lysine (Tri- epsilon-N-methyl)

L95-67R

Rabbit

WB, ELISA, IF, IHC, IP

 

3、磷酸化特異性抗體

該產(chǎn)品系列共包括82款磷酸化特異性抗體，下表僅列部分產(chǎn)品，

品名

貨號(hào)

宿主

應(yīng)用

Anti-phospho-14-3-3 beta (Ser58)

Y71-365R

Rabbit, IgG

WB, IHC

Anti-phospho-4EBP1 (Thr45)

E35-365R

Rabbit, IgG

WB, IHC

Anti-phospho-AKT1/2/3 (Ser473)

A16-65BR

Rabbit, IgG

WB, IHC

Anti-phospho-AKT1/2/3 (Thr308)

A16-65R

Rabbit, IgG

WB, IHC

Anti-phospho-ASK1 (Ser966)

M13-65R

Rabbit, IgG

IHC

Anti-phospho-ATF2 (Ser112)

A10-565R

Rabbit, IgG

IHC

Anti-phospho-ATF2 (Ser490 Ser498)

A10-565BR

Rabbit, IgG

WB, IHC

Anti-phospho-BRCA1 (Ser1423)

B87-365R

Rabbit, IgG

IHC

Anti-phospho-c-KIT (Tyr721)

K06-65R

Rabbit, IgG

WB

Anti-phospho-c-KIT (Tyr936)

K06-65BR

Rabbit, IgG

IHC

 

4、Primary Antibodies

該產(chǎn)品系列共包括279款原初抗體，下表僅列部分產(chǎn)品

 

品名

貨號(hào)

宿主

應(yīng)用

Anti-4EBP1

E35-563R

Rabbit, IgG

WB, ELISA, ICC

Anti-ADD1

A38-63R

Rabbit

WB

Anti-AFX

A42-63R

Rabbit

WB

Anti-AKT (pan)

A16-63R

Rabbit

WB

Anti-AKT (pan)

A16-63BR

Rabbit

WB

Anti-AKT1

A16-60M

Mouse, Monoclonal, 9A4

WB

Anti-AKT1

A16-63CR

Rabbit, IgG

WB, ELISA, IF, IHC

Anti-AKT2/3

A17-63BR

Rabbit

WB

Anti-ALK2

A06-63R

Rabbit, IgG

WB, ELISA

Anti-ALK4

A07-63R

Rabbit, IgG

WB, ELISA

 

5、二抗

品名

貨號(hào)

宿主

應(yīng)用

Anti-Mouse HRP

G32-62G

Goat Polyclonal

WB, ELISA

Anti-Rabbit HRP

G33-62G

Goat Polyclonal

WB, ELISA

 

6、Tag標(biāo)簽抗體

品名

貨號(hào)

宿主

應(yīng)用

Anti-DYKDDDDK

F51-61M

Mouse, IgG2b, FG4R

WB, ELISA, IP, IS

Anti-DYKDDDDK

F51-63R

Rabbit

WB

Anti-GFP

G46-60M

Mouse, IgG1, GF28R

WB

Anti-GST

G52-61M

Mouse, IgG2a, G2R

WB

Anti-HA

H98-61M

Mouse, IgG3, C10

WB, ELISA, IP, IS

Anti-HA

H98-63R

Rabbit Polyclonal

WB, ELISA, IP, IS

Anti-His

H99-61M

Mouse, IgG2b, EH158

WB, ELISA, IP, IS

Anti-His

H99-63R

Rabbit

WB, ELISA, IP, IS

Anti-Myc

M86-61M

Mouse, IgG1, M19

WB, ELISA, IP, IS

Anti-RFP

R46-61M

Mouse, IgG1, RF5R

WB

Anti-V5

V05-61M

Mouse, IgG1, V4RR

WB, ELISA, IP, IS

 

三、生物制劑產(chǎn)品系列

1、表觀遺傳酶激活劑

品名

貨號(hào)

CAS 注冊(cè)號(hào)

分子式

純度

BML-278

S35-904C

N/F

C24H25NO4

>98% (TLC)

CTPB

P07-903

586976-24-1

C31H43ClF3NO2

98%

Resveratrol

S35-904

501-36-0

C14H12O3

>98%

SirtAct

S35-904E

839699-72-8

C20H25N5O2

98% (TLC)

 

2、表觀遺傳酶抑制劑

該產(chǎn)品系列共包括33款表觀遺傳研究酶類的抑制劑，下表僅列部分產(chǎn)品

品名

貨號(hào)

應(yīng)用

2’-Deoxy-5-fluorocytidine

D353-904D

不可逆DNA甲基轉(zhuǎn)移酶抑制劑

5-Azacytidine

D353-904

DNA低甲基化試劑

AK-7

S36-904

SIRT2抑制劑

APICIDIN

H83-904B

HDAC抑制劑

BIX-01294 3HCl

S344-903

Histone甲基轉(zhuǎn)移酶抑制劑

BML-210

H83-904C

HDAC抑制劑

C-646

K311-903

HAT抑制劑

Chaetocin

K421-904C

Ly甲基轉(zhuǎn)移酶抑制劑

CPTH2

K311-903B

HAT 抑制劑

3、激酶激活劑

品名

貨號(hào)

CAS 注冊(cè)號(hào)

分子式

純度

8-pCPT-2-O-Me-cAMP-AM

R46-905

1152197-23-3

C20H21ClN5O8PS

>97% (HPLC)

AICAR

P47-900B

2627-69-2

C9H14N4O5

>99% (TLC); NMR (Conforms)

4、激酶抑制劑

該產(chǎn)品系列共包括80款常用激酶抑制劑，下表僅列部分產(chǎn)品

品名

貨號(hào)

應(yīng)用

6BIO

G08-900

GSK3 inhibitor

A83-01

A09-900

ALK inhibitor

AAL-993

F11-900C

VEGF inhibitor

AG-1296

P12-900

PDGFR Inhibitor

AG-1478

E10-900B

EGFR inhibitor

AG-1517

K11-900B

Tyrosine kinase inhibitor

5、磷酸酶抑制劑

品名

貨號(hào)

CAS 注冊(cè)號(hào)

分子式

純度

Cantharidin

P16-902C

56-25-7

C10H12O4

>98% (HPLC)

EX-527

S35-904F

49843-98-3

C13H13ClN2O

98% (TLC)

NSC-663284

C04-902

383907-43-5

C15H16ClN3O3

>98%

Okadaic acid, free acid

P16-902

78111-17-8

C44H68O13

>98% (TLC)

6、內(nèi)參siRNA

品名

貨號(hào)

beta-Actin Positive Control siRNA

A03-911D

Cy3 Labeled Negative Control siRNA

S02-910N

FAM Labeled Negative Control siRNA

S03-910N

GAPDH Positive Control siRNA

G13-911B

Unlabeled Negative Control siRNA

S01-910N

7、激酶研究常用siRNA

該產(chǎn)品系列共包括782款常用激酶的siRNA，下表僅列部分產(chǎn)品

品名

貨號(hào)

14-3-3 alpha/beta siRNA Set I

Y71-911

14-3-3 epsilon siRNA Set I

Y75-911

14-3-3 sigma siRNA Set I

Y86-911

14-3-3 theta siRNA Set I

Y84-911

14-3-3 zeta siRNA Set I

Y92-911

4EBP1 siRNA Set I

E35-911

AATK siRNA Set I

A02-911

ABL1 siRNA Set I

A03-911

ABL2 siRNA Set I

A04-911

ACK siRNA Set I

A05-911

ACVR2A siRNA Seti

A35-911

 

四、信號(hào)通路蛋白及酶

該產(chǎn)品系列包括目前常用的信號(hào)通路蛋白及相關(guān)酶類，品種多種多樣，包括：乙酰/甲基轉(zhuǎn)移酶系列、適配蛋白系列、凋亡通路系列、精氨酸脫亞氨酶系列、細(xì)胞周期蛋白系列、細(xì)胞應(yīng)激及分子伴侶蛋白系列、去乙酰化/甲基化酶系列、二氫嘧啶酶系列、雙加氧酶系列、果糖激酶系列、G-蛋白家族產(chǎn)品系列、激酶突變體產(chǎn)品系列、蛋白激酶產(chǎn)品系列、脂質(zhì)氧化酶系列、微管/肌動(dòng)蛋白相關(guān)蛋白產(chǎn)品系列、磷脂酶C家族產(chǎn)品系列、超氧化物歧化酶產(chǎn)品系列、Tau蛋白及其相關(guān)產(chǎn)品系列、轉(zhuǎn)錄因子產(chǎn)品系列、泛素蛋白產(chǎn)品系列以及無(wú)活性激酶產(chǎn)品系列。

五、信號(hào)通路相關(guān)檢測(cè)試劑

該產(chǎn)品系列包括檢測(cè)試劑、脂類酶底物、寡氨酸底物、肽底物、蛋白酶底物等產(chǎn)品系列。

六、胞外配體蛋白

該產(chǎn)品系列包括細(xì)胞趨化因子、細(xì)胞因子及生長(zhǎng)因子（生長(zhǎng)因子共134種，下表僅列部分）。

品名

貨號(hào)

應(yīng)用

IP-10

I838-40N

Cell Assay

RANTES (CCL5)

R801-40N

Cell Assay

SDF-1

S821-40N

Cell Assay

IFN-gamma

I837-40N

 

TNF-alpha

T860-40N

 

TNF-beta

T861-40BG

 

TNFB

T861-40N

 

TRAIL

T880-40N

 

 

SLC中國(guó)代理商上海起發(fā)實(shí)驗(yàn)試劑有限公司，是專業(yè)從事生命科學(xué)研究領(lǐng)域產(chǎn)品代理及部分生 物產(chǎn)品自主研發(fā)，以為科研人員提供高品質(zhì)科研產(chǎn)品為己任，是您值得信賴的科研伙伴！

 

 

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